Building embodied agents on integrating Large Language Models (LLMs) and Reinforcement Learning (RL) have revolutionized human-AI interaction: researchers can now leverage language instructions to plan decision-making for open-ended tasks. However, existing research faces challenges in meeting the requirement of open-endedness.

The exponential growth of large language models (LLMs) has opened up numerous possibilities for multimodal AGI systems. However, the progress in vision and vision-language foundation models, which are also critical elements of multi-modal AGI, has not kept pace with LLMs. In this work, we design a large-scale vision-language foundation model (InternVL), which scales up the vision foundation model to 6 billion parameters and progressively aligns it with the LLM, using web-scale image-text data from various sources. This model can be broadly applied to and achieve state-of-the-art performance on 32 generic visual-linguistic benchmarks including visual perception tasks such as image-level or pixel-level recognition, visionlanguage tasks such as zero-shot image/video classification, zero-shot image/video-text retrieval, and link with LLMs to create multi-modal dialogue systems. It has powerful visual capabilities and can be a good alternative to the ViT-22B. We hope that our research could contribute to the development of multi-modal large models.

Optical tomography has emerged as a non-invasive imaging method, providing three-dimensional insights into subcellular structures and thereby enabling a deeper understanding of cellular functions, interactions, and processes. Conventional optical tomography methods are constrained by a limited illumination scanning range, leading to anisotropic resolution and incomplete imaging of cellular structures. To overcome this problem, we employ a compact multi-core fibre-optic cell rotator system that facilitates precise optical manipulation of cells within a microfluidic chip, achieving full-angle projection tomography with isotropic resolution. Moreover, we demonstrate an AI-driven tomographic reconstruction workflow, which can be a paradigm shift from conventional computational methods, often demanding manual processing, to a fully autonomous process. The performance of the proposed cell rotation tomography approach is validated through the three-dimensional reconstruction of cell phantoms and HL60 human cancer cells. The versatility of this learning-based tomographic reconstruction workflow paves the way for its broad application across diverse tomographic imaging modalities, including but not limited to flow cytometry tomography and acoustic rotation tomography. Therefore, this AI-driven approach can propel advancements in cell biology, aiding in the inception of pioneering therapeutics, and augmenting early-stage cancer diagnostics.

In contrast to numerous NLP and 2D computer vision foundational models, the learning of a robust and highly generalized 3D foundational model poses considerably greater challenges. This is primarily due to the inherent data variability and the diversity of downstream tasks. In this paper, we introduce a comprehensive 3D pre-training framework designed to facilitate the acquisition of efficient 3D representations, thereby establishing a pathway to 3D foundational models. Motivated by the fact that informative 3D features should be able to encode rich geometry and appearance cues that can be utilized to render realistic images, we propose a novel universal paradigm to learn point cloud representations by differentiable neural rendering, serving as a bridge between 3D and 2D worlds. We train a point cloud encoder within a devised volumetric neural renderer by comparing the rendered images with the real images. Notably, our approach demonstrates the seamless integration of the learned 3D encoder into diverse downstream tasks. These tasks encompass not only high-level challenges such as 3D detection and segmentation but also low-level objectives like 3D reconstruction and image synthesis, spanning both indoor and outdoor scenarios. Besides, we also illustrate the capability of pre-training a 2D backbone using the proposed universal methodology, surpassing conventional pre-training methods by a large margin. For the first time, PonderV2 achieves state-of-the-art performance on 11 indoor and outdoor benchmarks. The consistent improvements in various settings imply the effectiveness of the proposed method. Code and models will be made available at https://github.com/OpenGVLab/PonderV2.

Cryo-electron microscopy (cryo-EM) captures snapshots of dynamic macromolecules, collectively illustrating the involved structural landscapes. This provides an exciting opportunity to explore the structural variations of macromolecules under study. However, traditional cryo-EM single-particle analysis often yields static structures. Here we describe OPUS-DSD, an algorithm capable of efficiently reconstructing the structural landscape embedded in cryo-EM data. OPUS-DSD uses a three-dimensional convolutional encoder–decoder architecture trained with cryo-EM images, thereby encoding structural variations into a smooth and easily analyzable low-dimension space. This space can be traversed to reconstruct continuous dynamics or clustered to identify distinct conformations. OPUS-DSD can offer meaningful insights into the structural variations of macromolecules, filling in the gaps left by traditional cryo-EM structural determination, and potentially improves the reconstruction resolution by reliably clustering similar particles within the dataset. These functionalities are especially relevant to the study of highly dynamic biological systems. OPUS-DSD is available at https://github.com/alncat/opusDSD.